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KMID : 0357920040380060388
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Korean Journal of Pathology
2004 Volume.38 No. 6 p.388 ~ p.393
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CD24 Expression in Gastric Adenocarcinoma Is Associated with Tumor Invasiveness
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Jung Kyeong-Cheon
Song Hun-Ho
Oh Kwon-Ik
Shin Hyung-Sik
Seo Jae-Nam
Park Young-Euy
Kim Tae-Woon
Choi Young-Mi
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Abstract
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Background: CD24, also referred to as the heat stable antigen in mice, is a glycosyl phosphatidylinositol-linked glycoprotein expressed by thymocytes, B cells, neutrophils and immature neuronal cells. It has been recently observed in a variety of human malignancy. Here, we demonstrated the expression of CD24 in gastric adenocarcinomas.
Methods: A total of 40 gastric adenocarcinomas and 20 tubular adenomas were immunohistochemically examined for the expression of CD24 and matrix metalloproteinase-2 (MMP-2) proteins. The immunoreactivity of CD24 was semiquantitatively scored (0, 1+, 2+) and compared with clinicopathologic variables and MMP-2 expression in tumor cells.
Results: CD24 was rarely expressed in normal gastric tissue and not expressed in tubular adenoma. In contrast, a moderate/strong expression (2+) of CD24 was observed in 25% of gastric adenocarcinomas, and 30% cases showed a weak CD24 staining (1+). Moreover, CD24 expression was significantly correlated with the depth of tumor invasion and MMP-2 expression.
Conclusions: These results suggest that the aberrant expression of CD24 in gastric adenocarcinomas might be associated with tumor progression and invasiveness.
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KEYWORD
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CD24 antigen, Stomach neoplasms, Neoplasm invasiveness, Matrix metalloproteinase-2
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